| Autor: |
Schmitt, Nathalie, Liu, Yang, Bentebibel, Salah-Eddine, Munagala, Indira, Bourdery, Laure, Venuprasad, K, Banchereau, Jacques, Ueno, Hideki |
| Předmět: |
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| Zdroj: |
Nature Immunology; Sep2014, Vol. 15 Issue 9, p856-865, 10p |
| Abstrakt: |
Understanding the developmental mechanisms of follicular helper T cells (TFH cells) in humans is relevant to the clinic. However, the factors that drive the differentiation of human CD4+ helper T cells into TFH cells remain largely undefined. Here we found that transforming growth factor-β (TGF-β) provided critical additional signals for the transcription factors STAT3 and STAT4 to promote initial TFH differentiation in humans. This mechanism did not appear to be shared by mouse helper T cells. Developing human TFH cells that expressed the transcriptional repressor Bcl-6 also expressed RORγt, a transcription factor typically expressed by the TH17 subset of helper T cells. Our study documents a mechanism by which TFH cells and TH17 cells emerge together in inflammatory environments in humans, as is often observed in many human autoimmune diseases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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