| Autor: |
Yukizawa, Yohei, Inaba, Yutaka, Kobayashi, Naomi, Ike, Hiroyuki, Kubota, So, Saito, Tomoyuki |
| Předmět: |
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| Zdroj: |
Modern Rheumatology; Sep2014, Vol. 24 Issue 5, p835-839, 5p |
| Abstrakt: |
Objectives. The purpose of this prospective study was to evaluate the utility of preferential application of pharmacoprophylaxis based on the quantitative evaluation by soluble fibrin (SF) and plasminogen activator inhibitor-1 (PAI-1) analysis on the day after total hip arthroplasty (THA). Methods. A hundred and sixteen patients were enrolled. High-risk patients were defined as those with elevated levels of SF or PAI-1, beyond their cut-off values, on the day after THA. For high-risk patients, fondaparinux was administered for 10 days postoperatively. When both plasma levels of SF and PAI-1 were less than their cutoff levels, the patients were regarded to be at low risk. For low-risk patients, only mechanical prophylaxis was applied. Results. Sixty patients (52%) were considered to be at high risk. Among them, venous thromboembolism (VTE) was detected in five patients (8%) by CT angiography. In addition, there were four patients (3%) who developed bleeding complications. Fifty-six patients (48%) were considered to be at low risk, and only one patient (2%) developed VTE. Conclusion. The measurement of SF and PAI-1 levels on the day after surgery may be helpful to identify the individual risk for postoperative VTE. According to this evaluation, a half of patients might not need to administer anticoagulant agents following surgery. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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