| Autor: |
Bielnaski, W., Ziemniak, W., Plonka, M., Dobrzanska, M.J., Kaminska, A., Konturek, S.J. |
| Předmět: |
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| Zdroj: |
Gut; Sep2002 Supplement 2, Vol. 51, pA98, 1/4p |
| Abstrakt: |
Background: The use of probiotics to enhance gastrointestinal integrity has been proposed for many years. Several studies clearly showed that these microorganisms have inhibitory effect also on H. pylori growth in vitro. Recently, Cremonini et al.(2001), demonstrated in vivo that supplementation with Lactobacillus acidophilus improved both tolerability and eradication rate of anti-H. pylori antibiotic-based therapy. This study was designed to evaluate the effectiveness of standard triple anti-H. pylori therapy supplemented with a commercially available in Poland preparation of probiotics. Subjects and Methods: 152 H. pylori positive symptomatic patients (confirmed by CLO-test, histology, and [sup 13]C-UBT) were enrolled to the study. 101 patients (group A) received 10-days standard anti Hp-therapy (pantoprazole 40 mg, amoxicillin 1 g b.i.d, clarithromycin 500 mg b.id), and 51 patients (group B) the same regimen but supplemented with commercially available probiotic preparations (Lacidofil, Rosell Inc., Canada) containing Lactobacillus rhamnosus and Lactobacillus acidophilus (2x109 CFU). To evaluate eradication rate [sup 13]C-UBT was performed 6 weeks after the beginning of the therapy. Two baseline breath samples were collected after a 6 hour fast followed by administration of capsulated low dose [sup 13]C-urea (40 mg). Post dose breath samples were collected at 10 and 20 minutes. Samples were analysed using a mass spectrometer (Heliview, Medichems, South Korea). A value of 3.5 delta over baseline was considered positive. Results: We found that out of ninety-nine patients of group A, who completed the anti-H. pylori therapy, 72% (71/99) were successfully eradicated. In group B (triple therapy plus probiotics) H. pylori eradication rate increased up to 92% (47/51) and was statistically significant (OR = 4.63; 95%CI: 1.42-16.73). No side affects were recorded during anti-H. pylori therapy supplemented with probiotics. Conclusions: The use of commercially... [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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