| Autor: |
Sia, C. S., Paul, E., Wale, R. J., Lynch, A. C., Heriot, A. G., Warrier, S. K. |
| Předmět: |
|
| Zdroj: |
Colorectal Disease; Sep2014, Vol. 16 Issue 9, p690-695, 6p |
| Abstrakt: |
Aim The study aimed to assess whether there has been an increase in the incidence of colorectal cancer ( CRC) among young patients in Victoria and whether such cancers are more advanced at presentation. Method The Victorian Cancer registry database was searched for patients, 18-50 years of age, diagnosed with CRC [young colorectal cancer ( YCRC)] between 2000 and 2010. Average annual percentage changes and incidence rate ratios ( IRRs) were calculated to characterize trends in CRC rates over time and to make comparisons with patients over 50 years of age with CRC [late colorectal cancer ( LCRC)]. Results Of 37432 CRCs registered during the study period, 2635 (7%) were in YCRC patients (annual increase in incidence = 1.7%; 95% CI: 0.5-2.9), compared with 34797 (93%) in LCRC patients (annual increase in incidence = 1.3%; 95% CI: 0.9-1.6). A small, nonsignificant increase in the incidence of YCRC over time was observed [ IRR = 1.004 (95% CI: 0.992-1.016) for YCRC vs 0.989 (95% CI: 0.986-0.992) for LCRC]. Rectal cancer was more common in YCRC patients than in LCRC patients (42% vs 34%, respectively; P < 0.0001). The cancer would have been seen on flexible sigmoidoscopy in 63% of YCRC patients compared with 53.6% of LCRC patients ( P < 0.0001). YCRC patients were more likely to have node-positive disease (49.3% YCRC patients vs 40% LCRC patients; P < 0.0001), especially those with colonic cancer (52.7% YCRC patients vs 41.2% LCRC patients; P < 0.0001). Conclusion There has been an increase in incident cases of YCRC. A small, nonsignificant increase in the incidence of YCRC over time was observed. Young patients are more likely to have rectal cancer and to be node positive. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text