| Autor: |
Keshvari, M., Hajibeigi, B., Azarkeivan, A., Keyvani, H., Behnava, B., Saiedi Hosseini, S. Y., Sharafi, H., Alavian, S. M. |
| Předmět: |
|
| Zdroj: |
Transfusion Medicine; Aug2014, Vol. 24 Issue 4, p227-232, 6p |
| Abstrakt: |
SUMMARY Background A large number of transfusion-dependent thalassemic patients is at a substantial risk for transfusion-transmitted infections. Human T-cell lymphotropic virus (HTLV) is a blood-borne pathogen and can be transmitted via cellular products. We aimed to evaluate the seroprevalence of HTLV in transfusion-dependent thalassemic patients referred to Tehran Adult Thalassemia Clinic. Methods From 2008 to 2010, 257 transfusion-dependent thalassemic patients who referred to Tehran Adult Thalassemia Clinic were enrolled. The seroprevalence of HTLV, hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV were assessed using enzyme-linked immunosorbant assay (ELISA). Also, the samples with positive result for anti-HTLVAb (by ELISA) were reassessed using Western blot for HTLV. Results Among the 257 transfusion-dependent thalassemic patients who were tested for anti-HTLVAb, 29 (11·3%, 95%CI = 7·8-15.6%) were found to be anti-HTLVAb positive by ELISA and Western blot. No case was detected to be HBsAg positive, whereas 16% had HBV seroconversion criteria, and more than 95% had anti-HBsAb in their sera. Also, 103 (40·1%) patients were HCV seropositive, 13 (5·1%) patients of which were co-infected with HCV/HTLV. Among the HTLV-infected patients, 44·8% were co-infected with HCV, whereas 39·5% of HTLV-seronegative individuals were HCV mono-infected ( P > 0·05). Conclusion This study showed that transfusion-dependent thalassemic patients were in higher risk for transmission of different blood-borne pathogens such as HTLV. The screening of HTLV in Iranian blood donors is recommended. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
