| Autor: |
Becker, Martina, Güttler, Steffen, Bachem, Annabell, Hartung, Evelyn, Mora, Ahmed, Jäkel, Anika, Hutloff, Andreas, Henn, Volker, Mages, HansWerner, Gurka, Stephanie, Kroczek, Richard A. |
| Předmět: |
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| Zdroj: |
Frontiers in Immunology; Jul2014, Vol. 5, p1-12, 12p |
| Abstrakt: |
In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function.We have recently shown that the chemokine receptor XCR1 is a lineage marker for cross-presenting DC in the spleen. Now, we provide evidence that intestinal XCR1+ DC largely, but not fully, overlap with CD103+ CD11b- DC, the hypothesized correlate of "cross-presenting DC" in the intestine, and are selectively dependent in their development on the transcription factor Batf3. XCR1+ DC are located in the villi of the lamina propria of the small intestine, theT cell zones of Peyer's patches, and in the T cell zones and sinuses of the draining mesenteric lymph node. Functionally, we could demonstrate for the first time that XCR1+/CD103+ CD11b- DC excel in the cross-presentation of orally applied antigen. Together, our data show that XCR1 is a lineage marker for cross-presenting DC also in the intestinal immune system. Further, extensive phenotypic analyses reveal that expression of the integrin SIRPa consistently demarcates the XCR1- DC population.We propose a simplified and consistent classification system for intestinal DC based on the expression of XCR1 and SIRPα. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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