| Autor: |
El Marroun, Hanan, White, Tonya J. H., van der Knaap, Noortje J. F., Homberg, Judith R., Fernández, Guill én, Schoemaker, Nikita K., Jaddoe, Vincent W. V., Hofman, Albert, Verhulst, Frank C., Hudziak, James J., Strieker, Bruno H. C., Tiemeier, Henning |
| Předmět: |
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| Zdroj: |
British Journal of Psychiatry; Aug2014, Vol. 205 Issue 2, p95-102, 8p |
| Abstrakt: |
Background Selective serotonin reuptake inhibitors (SSRls) are considered safe and are frequently used during pregnancy. However, two case-control studies suggested an association between prenatal SSRl exposure with childhood autism. Aims To prospectively determine whether intra-uterine SSSRI exposure is associated with childhood autistic symptoms in a population-based study. Method A total o f 376 children prenatally exposed to maternal depressive symptoms (no SSRl exposure), 69 children prenatally exposed to SSRls and 5531 unexposed children were included. Child pervasive developmental and affective problems we re assessed by parental rep ort with the Child Behavior Checklist at ages 1.5, 3 and 6. At age 6, we assessed autistic traits using the Social Responsiveness Scale (n = 4264). Results Prenatal exposure to maternal depressive symptoms without SSRls was related to both pervasive developmental (odds ratio (OR) = 1.44, 95% Cl 1.07-1.93) and affective problems (OR=1.44, 95% Cl 1.15-1.81). Compared with unexposed children, those prenatally exposed to SSRls also were at higher risk for developing pervasive developmental problems (OR=1.91, 95% Cl 1.13-3.47), but not for affective problems. Children prenatally exposed to SSRls also had more autistic traits (0= 0.15, 95% Cl 0.08-0.22) compared with those exposed to depressive symptoms only. Conclusions Our results suggest an association between prenatal SSRl exposure and autistic traits in children. Prenatal depressive symptoms without SSRl use were also associated with autistic traits, albeit this was weaker and less specific. Longterm drug safety trials are needed before evidence-based recommendations are possible. Declaration of interest F.C.V. is head o f the Department o f Child and Adolescent Psychiatry at Erasmus Medical Centre, which publishes the Achenbach System o f Empirically Based Assessment (ASEBA) and from which the department receives remuneration. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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