Direct Asymmetric Mannich-Type Reaction of α-Isocyanoacetates with Ketimines using Cinchona Alkaloid/Copper(II) Catalysts.

Autor:	Hayashi, Masashi, Iwanaga, Masaru, Shiomi, Noriyuki, Nakane, Daisuke, Masuda, Hideki, Nakamura, Shuichi
Předmět:	DIAMINO amino acids BIOACTIVE compounds IMINES CINCHONA alkaloids COPPER catalysts CARBONYL compounds
Zdroj:	Angewandte Chemie; Aug2014, Vol. 126 Issue 32, p8551-8555, 5p
Abstrakt:	The enantioselective direct Mannich-type reaction of ketimines with α-isocyanoacetates has been developed. Excellent yields and enantioselectivity were observed for the reaction of various ketimines and α-isocyanoacetates using cinchona alkaloid/Cu(OTf)2 and a base. Both enantiomers of the products could be obtained by using pseudoenantiomeric chiral catalysts. This process offers an efficient route for the synthesis of α,β-diamino acids. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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