NTBC Treatment of the Pyomelanogenic Pseudomonas aeruginosa Clinical Isolate PA1111 Inhibits Pigment Production and Increases Sensitivity to Oxidative Stress.

Autor:	Ketelboeter, Laura, Potharla, Vishwakanth, Bardy, Sonia
Předmět:	PSEUDOMONAS aeruginosa infections CYCLOHEXANEDIONES MICROBIAL sensitivity tests OXIDATIVE stress BACTERIAL pigments THERAPEUTICS BACTERIA
Zdroj:	Current Microbiology; Sep2014, Vol. 69 Issue 3, p343-348, 6p
Abstrakt:	Pyomelanin is a brown/black extracellular pigment with antioxidant and iron acquisition properties that is produced by a number of different bacteria. Production of pyomelanin in Pseudomonas aeruginosa contributes to increased resistance to oxidative stress and persistence in chronic infections. We demonstrate that pyomelanin production can be inhibited by 2-[2-nitro-4-(trifluoromethyl) benzoyl]-1,3-cyclohexanedione (NTBC). This treatment increases sensitivity of pyomelanogenic P. aeruginosa strains to oxidative stress, without altering the growth rate or resistance to aminoglycosides. As such, NTBC has potential to function as an anti-virulence factor in treating pyomelanogenic bacterial infections. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink