TNF-α gene promoter polymorphisms contribute to periodontitis susceptibility: evidence from 46 studies.

Autor:	Ding, Cheng, Ji, Xiaowei, Chen, Xing, Xu, Yan, Zhong, Liangjun
Předmět:	PERIODONTITIS CONFIDENCE intervals DATABASES GENES GENETIC polymorphisms MEDICAL information storage & retrieval systems MEDLINE META-analysis ONLINE information services REGRESSION analysis RESEARCH funding TUMOR necrosis factors SYSTEMATIC reviews DATA analysis software ODDS ratio DISEASE risk factors
Zdroj:	Journal of Clinical Periodontology; Aug2014, Vol. 41 Issue 8, p748-759, 12p, 6 Charts, 1 Graph
Abstrakt:	Aim Tumour necrosis factor-alpha ( TNF- α) plays a critical role in the pathogenesis of periodontal disease. TNF-α gene polymorphisms can influence the TNF- α production. Many studies have focused the association between TNF-α gene promoter polymorphisms and periodontitis risk, but these results are still controversial. Materials and Methods A meta-analysis was performed to assess the effect of TNF-α −308G/A (rs1800629), −238G/A (rs361525) and −863C/A (rs1800630) polymorphisms on either chronic ( CP) or aggressive periodontitis (AgP) risk. Odds ratios ( ORs) along with their 95% confidence intervals ( CIs) were calculated to assess the strength of the association. Forty-six studies involving 5186 cases and 6683 controls were retrieved and analyzed. Results The TNF-α −308G/A AA genotype was associated with increased CP risk in Asians, non-smoking Asians and Caucasians, and this polymorphism was significantly associated with elevated risk of AgP in Asians and Caucasians. Asian individuals carrying AA genotype had a significantly increased risk for −863C/A. No significant association was identified between TNF −238G/A polymorphism and CP. Conclusions These findings supported that TNF-α −308G/A and −863C/A polymorphisms may contribute to the susceptibility of periodontitis. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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