MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.

Autor: Malinin, Nikolai L., Boldin, Mark P.
Předmět:
Zdroj: Nature; 2/6/1997, Vol. 385 Issue 6616, p540, 5p, 8 Black and White Photographs, 4 Diagrams, 1 Graph
Abstrakt: Reports the cloning of a new protein kinase, NIK, which binds to Traf2 and stimulates transcription factor NF-kappaB activity. The similarity of NIK to MAPKK kinases; The participation of NIK in an NF-kappaB-inducing signalling cascade; The similarity to receptors of the tumor-necrosis/nerve-growth factor receptor family and the interleukin-1 type-I receptor.
Databáze: Complementary Index