European mitochondrial haplogroups are not associated with hepatitis C virus ( HCV) treatment response in HIV/ HCV-coinfected patients.

Autor:	Guzmán‐Fulgencio, M, Rallón, N, Berenguer, J, Fernández‐Rodríguez, A, Soriano, V, Miralles, P, Jiménez‐Sousa, MA, Restrepo, C, López, JC, García‐Álvarez, M, Aldámiz, T, Benito, JM, Resino, S
Předmět:	ANTIVIRAL agents CHI-squared test FISHER exact test GENETIC polymorphisms HEPATITIS C HIV infections MITOCHONDRIA RESEARCH funding U-statistics LOGISTIC regression analysis RETROSPECTIVE studies DATA analysis software
Zdroj:	HIV Medicine; Aug2014, Vol. 15 Issue 7, p425-430, 6p
Abstrakt:	Objectives Mitochondria are multifunctional organelles with a key role in the innate immune response against viral infections. Mitochondrial DNA ( mtDNA) haplogroups have been related to AIDS progression and CD4 T-cell recovery in HIV-infected patients, and to a delay in the development of liver fibrosis in HIV/hepatitis C virus ( HCV)-coinfected patients. We performed a study to investigate whether mtDNA haplogroups may be associated with HCV treatment response in HIV/ HCV-coinfected patients on pegylated interferon ( pegIFN) plus ribavirin ( RBV). Methods We performed a retrospective study in 304 patients who completed a course of HCV therapy. mtDNA polymorphisms were genotyped using Sequenom's MassARRAY platform. The interleukin-28B ( IL-28B) polymorphism (rs12980275) was genotyped using the GoldenGate® assay. Sustained virological response ( SVR) was defined as an undetectable HCV viral load at week 24 after the end of treatment. The statistical analysis was carried out using on-treatment data. Results The SVR rates were 52.6% (160 of 304) for all patients, and 37.8% (46 of 201) for patients with HCV genotype 1 or 4 vs. 81.4% (83 of 102) for patients with HCV genotype 2 or 3 ( P < 0.001). No significant associations were found between mtDNA haplogroup and SVR when all patients were included in the analysis and when patients were stratified by HCV genotype (i.e. those with genotypes 1/4 and 2/3 analysed separately) or IL-28B rs12980275 genotype. Conclusions European mtDNA haplogroups were not related to HCV treatment response in HIV/ HCV-coinfected patients on pegIFN-α/ RBV therapy. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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