Cardenolides from the bark of Calotropis gigantea.

Autor: Van Khang, Pham, Zhang, Zhong-Guo, Meng, Yu-Hui, Guo, De-An, Liu, Xuan, Hu, Li-Hong, Ma, Lei
Zdroj: Natural Product Research; Aug2014, Vol. 28 Issue 15, p1191-1196, 6p
Abstrakt: Three new cardenolides (1–3) were isolated from the 90% ethanolic extract of the bark of a wild-type Calotropis gigantea. Their structures were determined by using NMR spectra and LC-MS analysis. Their inhibitory activities were evaluated against non-small cell lung carcinoma (A549) and human cervix epithelial adenocarcinoma (HeLa) cell lines. Compounds 1 and 3 exhibited strong inhibitory effect on two cancer cell lines. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index