Syntheses of [14C]-labeled 2-(3-chlorophenyloxy)-3-[3-(3-hydroxy) pyridin-4-yl propoxy]pyridine, a phosphodiesterase 4 inhibitor and its metabolites.

Autor:	Ochi, Takeshi, Sawayama, Yusuke, Kawasaki, Motoji, Nigo, Tomohiro, Nakao, Masashi, Omodani, Tomoki, Sumiyoshi, Takaaki
Předmět:	PHOSPHODIESTERASES CHEMICAL synthesis OBSTRUCTIVE lung diseases PHARMACOKINETICS
Zdroj:	Journal of Labelled Compounds & Radiopharmaceuticals; Jun2014, Vol. 57 Issue 7, p477-479, 3p
Abstrakt:	We describe here the synthesis of [14C]-2-(3-chlorophenyloxy)-3-[3-(3-hydroxy)pyridin-4-yl propoxy]pyridine (1), a phosphodiesterase 4 inhibitor. [14C]-Labeled 1 was prepared in three steps from [14C]-2-bromopyridin-3-ol in an overall yield of 32%. Preparation of [14C]-labeled 2 and 3, two metabolites of 1, is also described. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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