Differences in immunogenicity and protection in mice and guinea pigs following intranasal immunization with Helicobacter pylori outer membrane antigens11This work was presented in part as abstract R-02 at the 11th International Workshop on Campylobacter, Helicobacter and Related Organisms, September 2001, Freiburg, Germany.

Autor: Keenan, Jacqueline I., Rijpkema, Sjoerd G., Durrani, Zarmina, Roake, Justin A.
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Zdroj: FEMS Immunology & Medical Microbiology; May2003, Vol. 36 Issue 3, p199, 7p
Abstrakt: Mice and guinea pigs were intranasally immunized with either recombinant lipoprotein 20 or Helicobacter pylori outer membrane vesicles (OMV). Cholera toxin was used as mucosal adjuvant. In mice, both vaccines elicited systemic and local IgG responses, which correlated with significantly lower levels of H. pylori colonization. In contrast, only OMV proved immunogenic in guinea pigs, with the development of both systemic and local immune responses. These antibodies did not, however, correlate with protection in these animals, which suggests that vaccine formulation is as important as choice of antigen in the development of an H. pylori vaccine. [Copyright &y& Elsevier]
Databáze: Complementary Index
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