Autor: |
Bolea, Irene, Colivicchi, Maria Alessandra, Ballini, Chiara, Marco ‐ Contelles, José, Tipton, Keith Francis, Unzeta, Mercedes, Della Corte, Laura |
Předmět: |
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Zdroj: |
CNS Neuroscience & Therapeutics; Jul2014, Vol. 20 Issue 7, p641-650, 10p |
Abstrakt: |
Background PF9601 N [ N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is an inhibitor of monoamine oxidase B ( MAO- B), which has shown to possess neuroprotective properties in several in vitro and in vivo models of Parkinson's disease ( PD). As there is evidence that excitotoxicity may be implicated in the pathophysiology of several neurodegenerative diseases, the aim of the present work was to investigate the effects of PF9601 N in an acute in vivo model of excitotoxicity induced by the local administration of kainic acid during striatal microdialysis in adult rats. Methods The basal and evoked release of neurotransmitters was monitored by HPLC analysis of microdialysate samples and tissue damage was evaluated histologically ' ex vivo.' Results PF9601 N (40 mg/kg, single i.p. administration) reduced the kainate-evoked release of glutamate and aspartate and increased taurine release, but it had no effect on the release of dopamine, DOPAC, and HVA. PF9601 N pretreatment also resulted in a significant reduction in the kainate-induced astrocytosis, microgliosis, and apoptosis. Conclusions The results suggest PF9601 N to be a good candidate for the treatment of neurodegenerative diseases mediated by excitotoxicity. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
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