Airway Inflammation and Illness Severity in Response to Experimental Rhinovirus Infection in Asthma.

Autor: Jie Zhu, Message, Simon D., Yusheng Qiu, Mallia, Patrick, Kebadze, Tatiana, Contoli, Marco, Ward, Christine K., Barnathan, Elliot S., Mascelli, Mary Ann, Onn M. Kon, Papi, Alberto, Stanciu, Luminita A., Jeffery, Peter K., Johnston, Sebastian L.
Předmět:
Zdroj: CHEST; Jun2014, Vol. 145 Issue 6, p1219-1229, 11p
Abstrakt: The article discusses a study that determined the association and response of bronchial mucosal inflammation with clinical and physiologic outcomes of exacerbations in rhinovirus-inducd asthma. Immunohistochemistry methods were used for detecting inflammatory cell phenotypes that infiltrate bronchial mucosa. Results showed significant increase in neutrophils, subepithelial and epithelial cells with rhinovirus infection at baseline along with higher monocyte/macrophage infiltration.
Databáze: Complementary Index