Long-Term Follow-Up of Patients with Chronic Chagas Disease and Implantable Cardioverter-Defibrillator.

Autor:	PEREIRA, FRANCISCA TATIANA MOREIRA, ROCHA, EDUARDO ARRAIS, MONTEIRO, MARCELO DE PAULA MARTINS, NETO, ALMINO CAVALCANTE ROCHA, DAHER, ELISABETH DE FRANCESCO, SOBRINHO, CARLOS ROBERTO MARTINS RODRIGUES, NETO, ROBERTO DA JUSTA PIRES
Předmět:	CARDIAC arrest prevention CARDIOMYOPATHIES CARDIAC output CHI-squared test CONFIDENCE intervals FISHER exact test HEART beat IMPLANTABLE cardioverter-defibrillators LONGITUDINAL method SURVIVAL analysis (Biometry) TRYPANOSOMIASIS PROPORTIONAL hazards models DATA analysis software DESCRIPTIVE statistics KAPLAN-Meier estimator DISEASE complications PROGNOSIS
Zdroj:	Pacing & Clinical Electrophysiology; Jun2014, Vol. 37 Issue 6, p751-756, 6p
Abstrakt:	Background/Objectives Chronic Chagas heart disease (ChHD) is associated with ventricular tachyarrhythmias and an increased risk of sudden cardiac death. Little is known about the effectiveness of implantable cardioverter-defibrillator (ICD) therapy in this population. The objective of this study was to evaluate the efficacy of ICD in patients with ChHD and to identify predictors of mortality and appropriate ICD shocks. Methods The cohort study included 65 patients with ChHD and ICD for primary and secondary prevention of sudden death. The Cox model was applied to evaluate the predictors of mortality, and survival was assessed by Kaplan-Meier analysis. Results The median age was 56 ± 11.9 years. The median follow-up was 40 ± 26.8 months. Among the patients 23 (36.5%) had appropriate shocks. A total of 13 (20%) patients died (6.1% of annual mortality rate), and there was no sudden death. In univariate Cox model, functional class IV (hazard ratio [HR] = 1.99; 95% confidence interval [CI], 1.05-3.76; P = 0.034), primary prevention (HR = 0.29; 95% CI, 0.09-0.99; P = 0.048), lower education (HR = 2.51; 95% CI, 1.05-5.99; P = 0.038), and ejection fraction <30% (HR = 2.80; 95% CI, 1.09-7.18; P = 0.032) were predictors of worse prognosis (death). In the multivariate Cox model, an ejection fraction <30% and the low education remained predictors of poor prognosis. Predictors of appropriate shocks were not found. Conclusions The ICD was effective for the prevention of sudden cardiac death in patients with chronic ChHD. An ejection fraction <30% and low education were predictors of poor prognosis. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.