| Autor: |
Du, Jingli, Wang, Yulan, Fu, Hanjiang, Zheng, Xiaofei, Lin, Minggui, Guo, Mingzhou, Wei, Lixin |
| Předmět: |
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| Zdroj: |
Chinese Science Bulletin; Jul2014, Vol. 59 Issue 19, p2249-2253, 5p |
| Abstrakt: |
Aberrant expression of microRNAs (miRNAs) was reported frequently in different human cancers. The major role of miRNA is targeting 3′-UTR of coding gene and causing translational repression or mRNA degradation. miR-10b overexpression was reported to promote breast cancer metastasis by up-regulating RHOC expression. But its expression in hepatocellular carcinoma (HCC) remains unclear. Our study indicated that the expression of miR-10b was different in HCC and adjacent tissue samples, and reduced expression of miR-10b in HCC was related to vein invasion. High-level expression of RHOC was also related to vein invasion in HCC. But no correlation was found between miR-10b and RHOC expression. These results suggest that miR-10b and RHOC are independent predictors of HCC invasion and metastasis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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