ATF7 IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children.

Autor:	Kobayashi, Kenichiro, Mitsui, Kazumasa, Ichikawa, Hitoshi, Nakabayashi, Kazuhiko, Matsuoka, Masaki, Kojima, Yasuko, Takahashi, Hiroyuki, Iijima, Kazutoshi, Ootsubo, Kaori, Oboki, Keisuke, Okita, Hajime, Yasuda, Kazuki, Sakamoto, Hiromi, Hata, Kenichiro, Yoshida, Teruhiko, Matsumoto, Kenji, Kiyokawa, Nobutaka, Ohara, Akira
Předmět:	LYMPHOBLASTIC leukemia in children CHROMOSOMAL translocation GENE expression PLATELET-derived growth factor TISSUE wounds MEDICAL screening
Zdroj:	British Journal of Haematology; Jun2014, Vol. 165 Issue 6, p836-841, 6p
Abstrakt:	We identified ATF7 IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B- ALL) and showed that B- ALL with ATF7 IP/ PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B- ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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