| Abstrakt: |
Abstract Aim: To compare the efficacy and the complications of three target levels of propofol plasma concentration in patients undergoing uterine dilation and curettage. Methods: Sixty-nine patients were randomly allocated to receive propofol target controlled infusion at different target concentrations of 4 (group I), 5 (group II) and 6 (group III) mcg/mL combined with 1 µg/kg of fentanyl and 66% of nitrous oxide. Patients’ movement during the procedure, hemodynamic variables, oxygen saturation, end tidal carbon dioxide, time to sleep and awake, and bispectral index score were recorded. Results: Seven patients in group I, one in group II, and none in group III (P < 0.05) moved grossly during the procedure. More patients in group III developed hypotension (5 vs 0 and 2 in group I and II, P < 0.05), but no difference was found regarding respiratory complication. No difference was found in time to sleep, but time to wake was longer in group III. Conclusion: Propofol infusion at the target concentration of 5 µg/mL was recommended for uterine dilation and curettage when it was administered with fentanyl 1 µg/kg and nitrous oxide 66% under close monitoring and appropriate respiratory management. [ABSTRACT FROM AUTHOR] |
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