| Autor: |
Sharma, Sandeep Kumar, Tilak, Mona A. |
| Předmět: |
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| Zdroj: |
Indian Journal of Public Health Research & Development; Apr-Jun2014, Vol. 5 Issue 2, p18-21, 4p |
| Abstrakt: |
Objective: The aim of the present study is to estimate the serum AST and ALT in alcoholic, nonalcoholic liver disease patients and in healthy controls for the assessment of Deritis to evaluate its clinical significance in differentiation of alcoholic liver disease from non-alcoholic liver disease. Method: 100 cases of each alcoholic and non-alcoholic hepatitis between the ages of 40-65 years were included in the study and 100 ages matched healthy individuals served as control. Serum AST and ALT levels were determined by enzymatic methods by kits obtained from CPC diagnostics. Results: It is found that AST and ALT levels are higher in both alcoholic as well as non-alcoholic hepatitis as compared to controls but it is statistically significant in case of alcoholic hepatitis. Similarly AST/ALT ratio is higher in both alcoholic and nonalcoholic hepatitis as compared to controls but it is statistically significant in case of alcoholic hepatitis only when compared to both non-alcoholic hepatitis and control. Conclusion: The findings of the present study suggest that in alcoholic hepatitis release of transaminases into the circulation in such a way that amount of AST released is more than that of ALT so that ratio of AST to ALT is significantly higher in case of ALD. Hence, the Deritis ratio can be considered as a reliable marker of ALD. Thus estimation of the Deritis ratio is essential to understand the nature of liver disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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