| Autor: |
Puelles, Eduardo, Acampora, Dario, Lacroix, Emmanuel, Signore, Massimo, Annino, Alessandro, Tuorto, Francesca, Filosa, Stefania, Corte, Giorgio, Wurst, Wolfgang, Ang, Siew-Lan, Simeone, Antonio |
| Předmět: |
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| Zdroj: |
Nature Neuroscience; May2003, Vol. 6 Issue 5, p453, 8p |
| Abstrakt: |
Organizing centers emit signaling molecules that specify different neuronal cell types at precise positions along the anterior-posterior (A-P) and dorsal-ventral (D-V) axes of neural tube during development. Here we report that reduction in Otx proteins near the alar-basal plate boundary (ABB) of murine midbrain resulted in a dorsal shift of Shh expression, and reduction in Otx proteins at the midbrain-hindbrain boundary (MHB) resulted in an anterior expansion of the Fgf8 domain. Our data thus indicate that an Otx dose-dependent repressive effect coordinates proper positioning of Shh and Fgf8 expression. Furthermore, this control is effective for conferring proper cell identity in the floor-plate region of midbrain and does not require an Otx2-spedfic property. We propose that this mechanism may provide both A-P and D-V positional information to neuronal precursors located within the midbrain. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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