| Autor: |
Shah, Divyen, Bond, Michelle, Kilby, Anne M., Patterson, Keith G. |
| Předmět: |
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| Zdroj: |
Leukemia & Lymphoma; Oct2001, Vol. 42 Issue 6, p1309-1314, 6p |
| Abstrakt: |
We describe a 11-year-old boy with acute myeloid leukaemia who presented with widespread bone disease. Spine X-rays revealed multiple crush fractures and there were multiple hot spots on the bone scan. The bone-mineral density was markedly reduced but there was no hypercalcaemia or hypercalcuria. Bone marrow aspirate revealed 98% blast cells and a balanced translocation between chromosomes 10 and 17 in seven of nine metaphases. Plasma interleukin-6 level before chemotherapy was high at 53 pg/ml. We postulate that the mechanism for bony destruction in this case was similar to that in the adult disease myeloma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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