| Abstrakt: |
Preclinical Research In the present study, the mechanism of action of MMPP (1 ‐ (4 ‐ methoxy ‐ 2 ‐ methylphenyl) piperazine) in the acquisition (pretraining administration), formation (posttraining administration), and consolidation (pretest administration) of memory was assessed in the passive avoidance test using a short ‐ and long ‐ term memory protocol in mice. MMPP modified avoidance in the acquisition and formation of memory protocols but not in the consolidation protocol. Scopolamine (0.1 mg/kg i.p.), dizocilpine (0.003 mg/kg i.p.), and buspirone (0.1 mg/kg i.p.) completely inhibited MMPP ‐ induced effects on memory acquisition and partially inhibited memory formation in the short ‐ term but not long ‐ term paradigm. This suggested that cholinergic, N ‐ methyl ‐ D ‐ aspartate (NMDA) and 5 ‐ hydroxytryptamine ‐ 1A (5 ‐ HT1A) receptors were implicated in the MMPP ‐ induced improvements in memory. The sedative, anxiolytic, motor impairment, myorelaxant, and anticonvulsive (pentylenetetrazole ‐ induced seizures) properties of MMPP were also assessed with the compound only showing a nondose ‐ dependent myorelaxation. These results suggest that MMPP can enhance acquisition and formation, but not consolidation, of memory in short ‐ term and long ‐ term protocol via cholinergic, NMDA ‐ glutamatergic, and 5 ‐ HT1A receptors. [ABSTRACT FROM AUTHOR] |
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