| Autor: |
Endro Nugroho, Agung, Kusumaramdani, Gina, Widyaninggar, Amalia, Prasetyo Anggoro, Dian, Pramono, Suwidjiyo |
| Předmět: |
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| Zdroj: |
International Food Research Journal; 2014, Vol. 21 Issue 2, p785-789, 5p |
| Abstrakt: |
Excessive food consumption regarding to high calorie, obesity, cardiovascular disease, stress, and lack of exercise are risk factors for diabetes mellitus (DM). One alternative therapeutic approach in DM patients is traditional use of herbal medicines such as Andrographis paniculata herbs. The aim of the study was to evaluate the antidiabetic effect of a combination of n-hexane insoluble fraction of A. paniculata herb (HIFA) with other traditional medicines i.e. curcuminoids fraction of Curcuma xanthorrhiza rhizome (CFC) or ethyl acetate soluble fraction of propolis (ESP) in high-fructose-fat-fed rats, a model of type 2 diabetes mellitus (DM) rats. These effects were compared to that of the single treatment of HIFA. The DM rats were induced by high-fructose-fat diet containing 36% fructose, 15% lard, and 5% egg yolks in 0.36 g/200 gb.wt for 60 days. The drugs were administered for 10 days, and the blood glucose levels were determined with an enzymatic colorimetric method (GOD-PAP). In the study, all combination exhibited hypoglycaemic effect in the high-fructose-fat-fed rats. Combination of HIFA and CFC showed a higher hypoglycaemic effect than that of the single treatment of HIFA. However, the hypoglycaemic effect of combination of HIFA and ESP was not more effective than that of the single treatment of HIFA. The combination HIFA-CFC is potential to develop as an antidiabetic agent. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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