Disclosure of Microbicide Gel Use to Sexual Partners: Influence on Adherence in the CAPRISA 004 Trial.
Autor: | Mngadi, Kathryn, Maarschalk, Silvia, Grobler, Anneke, Mansoor, Leila, Frohlich, Janet, Madlala, Bernadette, Ngcobo, Nelisiwe, Abdool Karim, Salim, Abdool Karim, Quarraisha |
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Předmět: |
HIV prevention
ANTI-infective agents CONFIDENCE intervals DRUGS EPIDEMIOLOGY FISHER exact test PHARMACEUTICAL gels HIV infections PATIENT compliance QUESTIONNAIRES RESEARCH funding STATISTICS T-test (Statistics) DISCLOSURE DATA analysis RANDOMIZED controlled trials BLIND experiment DATA analysis software SEXUAL partners DESCRIPTIVE statistics |
Zdroj: | AIDS & Behavior; May2014, Vol. 18 Issue 5, p849-854, 6p, 3 Charts |
Abstrakt: | Young women in sub-Saharan Africa are disproportionately affected by HIV, making the development of women initiated and controlled methods of prevention, including microbicides, a priority. Adherence is pivotal to microbicide efficacy and partner related factors are known to impact adherence. An analysis of disclosure of gel use to sexual partners and adherence in CAPRISA 004 women was conducted to better understand this relationship. Partner disclosure was significantly associated with a modest 4.2 % increased adherence (71.0 vs. 66.8 %, p = 0.03). Most women rated the experience of disclosure as positive, despite 6.7 % of partners expressing a negative reaction.Participants who disclosed were more likely to reside with their regular partner (14.4 vs. 8.4 %; p = 0.01) and reported consistent condom use at baseline (32.9 vs. 20.9 %; p < 0.01). Partner disclosure needs to be better understood as a potential facilitator or barrier to microbicide adherence. [ABSTRACT FROM AUTHOR] |
Databáze: | Complementary Index |
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