| Autor: |
Kaida, Katsuji, Ikegame, Kazuhiro, Ikemoto, Junko, Murata, Rie, Irie, Reiko, Yoshihara, Satoshi, Ishii, Shinichi, Okada, Masaya, Inoue, Takayuki, Tamaki, Hiroya, Soma, Toshihiro, Fujimori, Yoshihiro, Kai, Shunro, Ogawa, Hiroyasu |
| Zdroj: |
International Journal of Hematology; Apr2014, Vol. 99 Issue 4, p463-470, 8p |
| Abstrakt: |
In the present study, we analyzed the kinetics of serum soluble interleukin-2 receptor (sIL-2R) using data from 77 patients undergoing HLA-haploidentical transplantation using reduced-intensity conditioning (RIC), who were at an advanced stage or at high risk for relapse, to clarify the usefulness of sIL-2R as a biomarker of acute graft-versus-host disease (GVHD). Anti-T-lymphocyte globulin and methylprednisolone were used as GVHD prophylaxis. While the median sIL-2R in 38 patients not developing GVHD was suppressed at levels <740 U/ml, sIL-2R in 25 patients developing severe GVHD peaked on day 11 (1,663 U/ml), and thereafter decreased to <1,000 U/ml after day 30. The occurrence of GVHD was not limited to times of high sIL-2R level, but occurred at any time point on the sIL-2R curve. Most patients developing GVHD, however, experienced a higher sIL-2R level early in their transplant course. The combination of RIC and glucocorticoids sufficiently suppressed sIL-2R levels after HLA-haploidentical transplantation. In a multivariate analysis to identify factors associated with GVHD, day 7 sIL-2R >810 U/ml was the only factor significantly associated with the occurrence of severe GVHD ( p = 0.0101). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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