The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese.

Autor:	Yoshihara, Akihiro, Sugita, Noriko, Iwasaki, Masanori, Miyazaki, Hideo, Nakamura, Kazutoshi
Předmět:	OBESITY complications ACADEMIC medical centers ANALYSIS of variance BODY weight CELL receptors CONFIDENCE intervals EPIDEMIOLOGY GENES GENETIC polymorphisms PERIODONTAL disease POISSON distribution REGRESSION analysis RESEARCH funding T-test (Statistics) U-statistics DISEASE prevalence POSTMENOPAUSE DATA analysis software DESCRIPTIVE statistics OLD age
Zdroj:	Journal of Clinical Periodontology; May2014, Vol. 41 Issue 5, p460-466, 7p, 5 Charts, 1 Graph
Abstrakt:	Objectives The purpose of this study was to elucidate whether the association between beta-3 adrenergic receptor polymorphism and periodontal disease is modified by body weight. Material and Methods We enrolled 332 postmenopausal women and determined their HbA1C levels (%) and beta-3 adrenergic receptor (rs4994) genotypes. Periodontal parameters including clinical attachment level ( CAL) were measured. After selecting subjects for each body mass index ( BMI) level, the prevalence rate ratio ( PRR) by multiple Poisson regression analysis was calculated to evaluate the relationship between periodontal disease and beta-3 adrenergic receptor polymorphism. The number of sites with CAL≥6 mm was used as a dependent variable, and beta-3 adrenergic receptor genotype [categorized as Arg non-carriers (reference) or Arg carriers], age (y) and HbA1C (%) were adopted as independent variables. We converted the number of probing sites ( n) to an offset variable. Results The PRR of the beta-3 adrenergic receptor genotype for the number of sites of CAL≥6 mm showed a positive association in subjects with BMI≥25.0 and increased markedly with BMI. The PRR in subjects with BMI≥30 was 3.10 ( p < 0.0001). Conclusion This study indicates a positive association between periodontal disease and the beta-3 adrenergic receptor genotype in obese individuals. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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