| Abstrakt: |
Background and Objectives: Epidemiological studies have demonstrated an association between periodontal disease and cardiovascular diseases. Evidences confirm fibrinogen and ESR as independent predictors of coronary heart diseases. However studies focusing fibrinogen and ESR as markers of systemic inflammatory response in patients with periodontitis are inconclusive. This study estimated the plasma levels of fibrinogen and ESR as markers of systemic inflammation in periodontitis patients. Material and Methods: Group I - 30 patients with healthy periodontium. Group II - 20 patients with mild to moderate periodontitis. Group III - 20 patients with severe periodontitis. Parameters like Plaque index, Probing Pocket Depth, Clinical Attachment Level, BMI, ESR, lipid profile and plasma levels of fibrinogen were measured for all patients. Results: The results showed that mean plasma levels of fibrinogen were significantly higher for patients with severe chronic periodontitits [415.45±171.90 (SD)] as compared to patients with mild to moderate periodontitis [305.85±63.64 (SD)] and controls [296.90±134.49 (SD)]. However, there were no statistically significant differences in the ESR values among the three groups. There was also no statistically significant correlation of fibrinogen with ESR values. Conclusion: Fibrinogen is a definite marker for presence and severity of systemic inflammatory response in chronic periodontitis patients and its elevated levels may be the indicator of the link between cardiovascular diseases and periodontitis. [ABSTRACT FROM AUTHOR] |
