| Autor: |
Azebaze, Anatole Guy, Menasria, Faouzia, Noumi, Lylie Gwladys, Nguemfo, Edwige Laure, Tchamfo, Marie Fomani, Nkengfack, Augustin Ephrem, Kolb, Jean Pierre, Meyer, Mich�le |
| Zdroj: |
Planta Medica; 2009, Vol. 75 Issue 3, p243-248, 6p |
| Abstrakt: |
Phytochemical investigations of the seeds of Allanblackia monticola have led to the isolation and characterization of one new xanthone derivative, named allanxanthone E (1), together with seven known compounds, including five xanthones, 1,7-dihydroxy-3-methoxy-2-(3-methylbut-2-enyl)xanthone (2), α-mangostin (3), garciniafuran (4), allanxanthone C (5), and 1,6-dihydroxy-2,4-diprenylxanthone (6), and two pentacyclic triterpenes, friedelin and lupeol. The structures of these compounds were established on the basis of one- and two-dimensional NMR homo- and heteronuclear correlation evidence. Some of these compounds were evaluated for their apoptotic and antiproliferative activities against human leukemic B lymphocytes, such as the hairy cell leukemia-derived ESKOL cell line and cells from B-CLL (B-cell chronic lymphocytic leukemia) patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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