| Abstrakt: |
This account relates the thought processes that went into solving synthetic problems, mostly related to steroids, submitted by industry and, in many cases, the evolution of the solutions into new reactions more generally useful in organic synthesis. A strong emphasis is placed on mechanistic considerations and serendipitous findings as the main basis for constructing working hypotheses from which novel reactions were derived. 1 Introduction 2 Early Steroid Problems 2.1 A Pleasant Encounter with Isocyanides 2.2 The Nitro Route to Corticosteroids 2.3 Explorations in Nitro Chemistry 3 The 16β-Methyl Problem 4 A Problem of Bile Acid Side-Chain Degradation 4.1 Planned and Unexpected Oxazoline Chemistry 4.2 New Reactions of Sulfines 4.3 An Unusual Route to Trifluoromethyl Ketones 5 From Enamides to Radical Chemistry 6 Solutions Waiting for Problems [ABSTRACT FROM AUTHOR] |
