Synthesis of Carbon E,E-Diene Chain-Linked Dinucleotide Analogues.

Autor: Fargeas, Val�rie, An�, Adjou, Dubreuil, Didier, Lebreton, Jacques
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Zdroj: Synlett; 2009, Issue 20, p3341-3345, 5p
Abstrakt: The synthesis of a dinucleotide thymidine-thymidine linked by a carbon E,E-diene chain is described. This dimer is synthesized by a coupling reaction between an (E)-vinylstannane and an (E)-iodovinyl partner prepared from acetylenic parents, which are both available from thymidine in six and five steps, respectively. In addition, a new efficient access to 3′-C-formyl thymidine is presented. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index