| Autor: |
Benes, Francine M., Walsh, John, Bhattacharyya, Sujoy, Sheth, Archna, Berretta, Sabina |
| Předmět: |
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| Zdroj: |
Archives of General Psychiatry; Apr2003, Vol. 60 Issue 4, p359, 6p |
| Abstrakt: |
Background: Apoptosis is thought to play a role in neuronal pathology in schizophrenia and bipolar disorder. Methods: To test this hypothesis, the Klenow method for in situ end-labeling of single-stranded DNA breaks was applied to anterior cingulate cortex from 18 healthy controls, 18 schizophrenic subjects, and 10 bipolar subjects. Results: An unexpected reduction (71%) in Klenow-positive nuclei was found in schizophrenic but not in bipolar cortexes. Conclusions: To our knowledge to date, this is the first demonstration that there is much less DNA fragmentation in individuals with schizophrenia than in healthy controls and bipolar subjects, which raises a key question as to whether this alteration represents an adaptive or nonadaptive change in the regulation of intracellular signaling and mitochondrial oxidative pathways associated with apoptosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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