| Autor: |
Campbell, James B., Sparks, Richard B., Dedinas, Robert F. |
| Předmět: |
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| Zdroj: |
Synlett; 2011, Issue 3, p357-360, 4p |
| Abstrakt: |
Samarium(III) tris[hexamethyldisilazide] (Sm[(Me3Si)2N]3 = Sm[HMDS]3) promotes the direct conversion of an ester admixed with an amine into the corresponding carboxamide under exceptionally mild conditions (≤0 ˚C) and in high yields. Only a slight excess of amine and the lanthanide complex are required to effect complete conversion of the ester into the amide. Esters with acidic α-hydrogens undergo a competing Claisen-like condensation along with the desired conversion into amides. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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