| Autor: |
Hofmann, Tatjana, Altmann, Karl-Heinz |
| Předmět: |
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| Zdroj: |
Synlett; 2008, Issue 10, p1500-1504, 5p |
| Abstrakt: |
The total synthesis of the natural product L-783277 (1) has been accomplished based on the convergent assembly of building blocks 9, 10, and 14. Key steps are the Suzuki coupling of olefin 11 and aromatic building block 14, the Mitsunobu-based macrolactonization of seco acid 16, and the allylic oxidation of the macrocyclic triol 2 with polymer-bound IBX. Only one of the two C6′-stereoisomers of 2 provided L-783277 (1) with high selectivity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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