NOBIN-Prolinamide Organocatalyzed Enantioselective Direct Aldol Reaction: Remarkable Activity in Apolar Medium.

Autor: Russo, Alessio, Botta, Giovanna, Lattanzi, Alessandra
Předmět:
Zdroj: Synlett; 2007, Issue 5, p0795-0799, 5p
Abstrakt: Amides easily obtained from enantiopure (R)- and (S)-NOBIN and l-proline have been shown to promote the enantioselective direct aldol reaction under low catalytic loadings (5 mol%), in apolar hexane as the solvent and using only a slightly higher �molar excess of the acetone with respect to the aldehyde. Aldol products are isolated in good to high yields and up to 77% ee at room temperature. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index