Cover Picture: Diphenylacetylene-Linked Peptide Strands Induce Bidirectional β-Sheet Formation (Angew. Chem. Int. Ed. 14/2014).

Autor: Lingard, Hannah, Han, Jeongmin T., Thompson, Amber L., Leung, Ivanhoe K. H., Scott, Richard T. W., Thompson, Sam, Hamilton, Andrew D.
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Zdroj: Angewandte Chemie International Edition; Apr2014, Vol. 53 Issue 14, p3521-3521, 1p
Abstrakt: β‐Sheets, key secondary structural elements of folded proteins, are commonly involved in therapeutically important protein–protein interactions and are a critical constituent of amyloid deposits in many neurodegenerative conditions. In their Communication on page 3650 ff., A. D. Hamilton, S. Thompson, et al. reveal a strategy for mediating these interactions through the use of a tetrasubstituted diphenylacetylene to induce the formation of β‐sheet structures in two directions (illustration by Dr. Karl Harrison). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index