Effect of peptide geroprotectors on navigation learning in rats of different ages and caspase-3 systems in their brain structures.

Autor: Mendzheritskii, A., Karantysh, G., Abramchuk, V., Ryzhak, G.
Zdroj: Advances in Gerontology; Jan2014, Vol. 4 Issue 1, p37-41, 5p
Abstrakt: The effects of peptide geroprotectors, such as cortexin and pinealon, on the training of rats of different ages and the caspase-3 system in their brain structures were studied in the experimental model of acute hypoxic hypoxy. Regional changes were identified in the activity and the content of caspase-3 in the cerebral cortex and brainstem structures of young and old rats under the influence of peptide preparations. It is suggested that the functional state of the caspase-3 system in the brain is one of the reasons for the ability of animals to learn. Compared with cortexin, pinealon has a greater positive effect on the learning of both young and old animals in the Morris labyrinth. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index