| Autor: |
García-Mediavilla, Victoria, Villares, Carmen, Culebras, Jesús M., Bayón, Jose E., González-Gallego, Javier |
| Předmět: |
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| Zdroj: |
Pharmacology & Toxicology; Feb2003, Vol. 92 Issue 2, p94, 6p |
| Abstrakt: |
β-Cyclodextrin is a compound that forms inclusion complexes with a variety of molecules, specially bile acids and sterols. This study examines the effects of β-cyclodextrin on cholesterol and bile acid metabolism in hypercholesterolaemic rats. Male Wistar rats were divided into 4 groups that received during 7 weeks: control diet, 2% cholesterol diet (A), A+2.5% β-cyclodextrin (B) and A+5% β-cyclodextrin (C). The cholesterol-rich diet induced hepatomegaly and fatty liver and significantly reduced cholesterol, bile acid and phospholipid secretion. Addition of β-cyclodextrin normalised biliary lipid secretion. Moreover, when compared to A, β-cyclodextrin significantly lowered plasma phospholipid concentration (B: -21%; C: -29%) and the liver free/total cholesterol molar ratio (B: -40%; C: -38%), increased bile acid faecal output (B: + 17%; C: +62%) and enhanced cholesterol 7α-hydroxylase activity (B:+50%; C: + 100%) and mRNA levels (B: + 14%; C: +29%). 5% β-cyclodextrin also reduced plasma triglycerides concentration (-38%). However, ALT and AST activities were significantly increased (B: +140% and +280%; C: +72% and +135%) and there was a high incidence of cell necrosis with portal inflammatory cell infiltration. Addition of β-cyclodextrin to a cholesterol-rich diet results in a triglyceride-lowering action, enhancement of bile acid synthesis and excretion, and normalization of biliary lipid secretion, but produces a marked hepatotoxic effect. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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