In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons.

Autor: Yan, Qiao, Matheson, Christine
Předmět:
Zdroj: Nature; 1/26/1995, Vol. 373 Issue 6512, p341, 4p, 2 Black and White Photographs, 2 Graphs
Abstrakt: Investigates the potential motor neuron neurotrophic effects of glial-cell-line-derived neurotrophic factor (GDNF), initially identified as a neurotrophic factor for substantia nigra dopaminergic neurons. Transport of GDNF in a receptor-mediated fashion by spinal cord motor neurons in neonatal rats; Prevention of massive motor neuron cell death and atropy by local application of GDNF to the transfected facial nerve.
Databáze: Complementary Index