| Autor: |
Ma'ani Hessari, Nason, Spindler, Lea, Troha, Tinkara, Lam, Wan‐Chi, Drevenšek‐Olenik, Irena, Webba da Silva, Mateus |
| Předmět: |
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| Zdroj: |
Chemistry - A European Journal; Mar2014, Vol. 20 Issue 13, p3626-3630, 5p |
| Abstrakt: |
The ability to produce, reproducibly and systematically, well-defined quadruplex DNA nanowires through controlled rational design is poorly understood despite potential utility in structural nanotechnology. The programmed hierarchical self-assembly of a long four-stranded DNA nanowire through cohesive self-assembly of GpC and CpG 'sticky' ends is reported. The encoding of bases within the quadruplex stem allows for an uninterrupted π-stacking system with rectilinear propagation for hundreds of nanometers in length. The wire is mechanically stable and features superior nuclease resistance to double-stranded DNA. The study indicates the feasibility for programmed assembly of uninterrupted quadruplex DNA nanowires. This is fundamental to the systematic investigation of well-defined DNA nanostructures for uses in optoelectronic and electronic devices as well as other structural nanotechnology applications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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