| Autor: |
Purroy, F., Suárez ‐ Luis, I., Mauri ‐ Capdevila, G., Cambray, S., Farré, J., Sanahuja, J., Piñol ‐ Ripoll, G., Quílez, A., González ‐ Mingot, C., Begué, R., Gil, M. I., Fernández, E., Benabdelhak, I. |
| Předmět: |
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| Zdroj: |
European Journal of Neurology; Apr2014, Vol. 21 Issue 4, p679-683, 5p, 2 Charts |
| Abstrakt: |
Background and purpose The etiological classification of patients with transient ischaemic attack ( TIA) is a difficult endeavor and the use of serum biomarkers could improve the diagnostic accuracy. The aim of this study was to correlate atrial fibrillation, the main cardioembolic etiology ( CE), with different serum biomarkers measured in consecutive TIA patients. Methods The concentrations of interleukin-6 ( IL-6), tumor necrosis factor-alpha, neuron-specific enolase, high-sensitivity C-reactive protein, IL-1-α and the N-terminal pro-B type natriuretic peptide ( NT-pro BNP) were quantified in the serum of 140 patients with TIA and 44 non-stroke subjects. Measurements were performed at different times throughout evolution: within 24 h of symptoms onset and at days 7 and 90. Results With the exception of IL-6, all biomarkers were higher in TIA patients than in controls. NT-proBNP was significantly related to the presence or new diagnosis of AF at all time points analyzed. Furthermore, the baseline NT-proBNP level was significantly higher than values at the 7-day and 90-day follow-up. For this reason, different cut-off values were obtained at different times: 313 pg/ml at baseline [odds ratio (OR) = 18.99, P < 0.001], 181 pg/ml at 7 days (OR = 11.4, P = 0.001) and 174 pg/ml (OR = 8.46, P < 0.001) at 90 days. Conclusion High levels of NT-pro BNP determined during the first 3 months after a TIA were associated with AF. Consequently, this biomarker may be useful to reclassify undetermined TIA patients as having disease of CE. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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