| Autor: |
Cupisti, K., Lehwald, N., Anlauf, M., Riemer, J., Werner, T. A., Krieg, A., Witte, J., Chanab, A., Baldus, S. E., Krausch, M., Raffel, A., Herdter, C., Schott, M., Knoefel, W. T. |
| Předmět: |
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| Zdroj: |
Hormone & Metabolic Research; Feb2014, Vol. 46 Issue 2, p138-144, 7p |
| Abstrakt: |
The management of papillary microcarcinoma (PMC) of the thyroid is controversial, especially after partial thyroid resection for benign thyroid disease. In order to detect prognostic factors for PMC, we analyzed 116 patients with PMC for encapsulation status and lymph node metastases. Between 10/1992 and 12/2010, 116 patients with PMC have been operated in our department (87 females, 29 males, median age 49 years). Eighty per cent of PMCs were diagnosed postoperatively. Seventy-six patients (66 %) received a more extended resection with either thyroidectomy, near total thyroidectomy, or Dunhill operation either primarily or after completion operation, whereas 40 patients (34 %) had only partial resection. Fifty patients (43 %) received radioiodine (RIA) ablation. Lymph node metastases were found in 21 patients (18 %). Univariate analysis showed four risk factors to be signifi cantly associated with the risk of lymph node metastasis (p < 0.05): male gender, younger age, age group < 50 years and nonencapsulation of the tumor. Multivariate analysis demonstrated statistical significance for gender and tumor capsulation status. The tumor capsulation status also correlated with tumor multifocality. Our data show that the risk of lymph node metastases is significantly higher in partially or nonencapsulated PMC than in encapsulated specimens. We therefore suggest that the WHO classification should be extended to a compulsory notifi cation of the encapsulation status in PMC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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