Changes in Prevalence of Prescription Opioid Abuse after Introduction of an Abuse-Deterrent Opioid Formulation.
| Autor: | Cassidy, Theresa A., DasMahapatra, Pronabesh, Black, Ryan A., Wieman, Matthew S., Butler, Stephen F. |
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| Předmět: |
SUBSTANCE abuse prevention
ANALGESICS AUTOMATIC data collection systems CONFIDENCE intervals NARCOTICS SCIENTIFIC observation PHARMACEUTICAL chemistry QUESTIONNAIRES STATISTICAL sampling SELF-evaluation SUBSTANCE abuse LOGISTIC regression analysis OXYCODONE PRE-tests & post-tests DATA analysis software DESCRIPTIVE statistics |
| Zdroj: | Pain Medicine; Mar2014, Vol. 15 Issue 3, p440-451, 12p, 4 Charts, 2 Graphs |
| Abstrakt: | Objective The reformulation of oxycodone hydrochloride controlled-release ( CR) tablets in August 2010 created a natural experiment at a national scale, providing an opportunity to evaluate patterns of abuse of prescription opioids and other drugs before and after introduction of this abuse-deterrent formulation ( ADF). Design Observational, cross-sectional study Setting Sentinel sample of adults assessed for substance abuse treatment within the NAVIPPRO® surveillance system Subjects Two hundred thirty-two thousand and eight hundred seventy-four adults at 437 facilities during January 1, 2008 through December 31, 2011. Methods Time-series analysis using logistic regression to estimate quarterly prevalence of past 30-day abuse (adjusted for covariates and prescription volume) and changes in abuse pre-and post- ADF introduction. Results Increases in abuse prevalence occurred for all prescription opioids as a class and for extended-release ( ER) opioids. Significantly greater abuse of ER oxymorphone and buprenorphine occurred in the post- ADF period (relative risk [ RR] = 2.91, 95% confidence interval [ CI] = 2.59-3.27 and RR = 1.85, 95% CI = 1.74-1.96). Increases in abuse for these two compounds were significant among groups who reported abuse via preferential routes of administration (oral only, snorting only, injection only) post-ADF introduction. Conclusions Replacement of a widely prescribed opioid formulation known for its abuse potential alone may have had little impact on overall rates of prescription opioids as a class. However, changes in abuse levels of certain opioids coinciding with ADF introduction suggest possible switching of abuse among this study sample to specific long-acting opioid analgesics. Additional follow-up studies will be important to monitor changing abuse patterns and their public health impact as new opioid formulations are developed and introduced to market. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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