| Autor: |
Krebs, Nancy F., Westcott, Jamie L., Rodden, Donna J., Ferguson, Katharine W., Miller, Leland V., Hambidge, K. Michael |
| Zdroj: |
American Journal of Clinical Nutrition; Dec2006, Vol. 84 Issue 6, p1340-1343, 4p |
| Abstrakt: |
Background: Small-for-gestational-age (SGA) infants are susceptible to postnatal zinc deficiency, but whether this susceptibility is due to intrauterine factors or to high postnatal growth requirements is unknown. Objective: We hypothesized that the size of the exchangeable zinc pool (EZP), which reflects metabolically available zinc, would be smaller in SGA than in appropriate-for-gestational-age (AGA) infants born prematurely. Design: Intravenous 70Zn (45 μ/kg) was administered to 10 SGA infants (8 boys) with a mean (±SD) gestational age of 33.3±1.8 wk and to 11 AGA infants (8 boys) with a mean (±SD) gestational age of 32.4±1.2 wk within 24 h of birth. The EZP was determined from isotope enrichment in spot urine collections on days 3-7. Results: The mean birth weight of the SGA infants was 1.30 ± 0.2 kg and of the AGA infants was 1.84±0.3 kg (P=0.0001). The EZP size was significantly smaller in the SGA than in the AGA infants on an absolute basis (13.3 ± 2.8 and 25.2 ± 8.1 mg; P =0.0002) and relative to body weight (10.3±2.5 and 13.9±4.5 mg/kg;P=0.02). The difference remained significant after adjustment for gestational age and birth weight. Conclusion: These data provide evidence for differential zinc status at birth between SGA and AGA infants born prematurely at similar stages of gestation and offer at least a partial explanation for the reported benefits of postnatal zinc supplementation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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