Decreased systemic thromboxane A2 biosynthesis in normal human subjects fed a salmon-rich diet.

Autor: Prakash, Chandra, Nelson, Gary J., Mei-Miau Wu, Schmidt, Perla C., Phillips, Mark A., Blair, Ian A.
Předmět:
Zdroj: American Journal of Clinical Nutrition; Sep1994, Vol. 60 Issue 3, p369-373, 5p
Abstrakt: Nine normal male subjects were fed a reference diet typical of that consumed in the United States and a diet containing ≈450 g salmon (salmon-rich diet). The salmon diet contained ≈6 g ω3 fatty acids that comprised 2.0% energy intake/d for each individual. The percent energy contribution of protein, carbohydrate, and fat (19%, 56%, and 25%, respectively) was identical for the two diets. Urinary excretion of 2,3-dinor-thromboxane B2 was significantly lower (0.74 ± 0.26 ng/24 h) with the salmon diet compared with the reference diet (0.95 ± 0.31 ng/24 h). In addition, in vitro generation of thromboxane B2 in response to collagen-stimulated aggregation of platelet-rich plasma from subjects consuming the salmon diet was reduced (1.87 ± 0.79 ng/mL) compared with subjects consuming the reference diet (3.10 ± 1.81 ng/mL). Urinary 2,3-dinor-6-oxo-prostaglandin F excretion in subjects was not significantly different between the salmon diet (0.69 ± 0.33 ng/24 h) and the reference diet (0.81 ± 0.44 ng/24 h). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index