| Autor: |
Phinney, Stephen D., Fisler, Janis S., Tang, Anna B., Warden, Craig H. |
| Předmět: |
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| Zdroj: |
American Journal of Clinical Nutrition; Jul1994, Vol. 60 Issue 1, p61-67, 7p |
| Abstrakt: |
To determine whether there is altered liver lipid-fraction fatty acid distribution in a multigenic obese mouse model, we examined livers from eight lean (0.2-4.2% carcass fat), seven intermediate (5.7-13.8%), and five obese (20.2-48.7%) backcross progeny [(C57BL/6J x Mus spretus) x C57BL/6J] aged 2-3 mo. Thirteen males and seven females were fed a nonpurified stock diet. Liver lipid fractions were separated and fatty acids quantitated by thin-layer and gas chroma-tography. There was a significant effect of obesity on 18:2ω6 in liver phospholipids (PL), cholesteryl esters, and triglycerides. PL 18:2ω6 was negatively correlated with carcass fat (r = -0.74, P <0.001); 20:3ω6 was elevated in PL with increased obesity (P <0.0001), and was correlated with carcass fat (r = 0.92, P <0.0001); and 20:4ω>6 in PL did not differ with obesity status. PL 20:3ω6 and 20:4ω6 were lower in males (P < 0.01 and 0.02, respectively) than in females. We conclude that obesity and sex affect distribution of uω6 essential fatty acids in mouse liver lipid fractions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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