| Autor: |
Wolfsdorf, Joseph I., Ehrlich, Sonia, Landy, Hal S., Crigler Jr, John F. |
| Předmět: |
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| Zdroj: |
American Journal of Clinical Nutrition; Sep1992, Vol. 56 Issue 3, p587-592, 6p |
| Abstrakt: |
To determine the optimal daytime dietary regimen for type 1 glycogen storage disease (GSD), we used uncooked cornstarch (UCS) at a basal glucose production rate (GPR) in single and divided doses, with mixed meals at 0700 and I 700 h. This regimen was compared with a 1 .5 times larger single dose of UCS at 0700 h, and with dextrose at GPR at 1200 h. Two-hour UCS loads (amount equal to GPR in 2 h) given with a mixed meal at 0700 h and I 80 mm later maintained mean blood glucose (BG) concentrations at ≥4.2 mmol/L for 300 mm. BG was significantly greater from 240 to 300 mm compared with a single 4-h UCS load, and at 300 mm compared with a single 6-h UCS load. Similar effects were noted when the divided UCS regimen was given with a mixed meal at 1700 h, but not when isoenergetic amounts of dextrose were given on the same schedules with a mixed meal at 1200 h. A daytime schedule of six UCS feedings (with the three main meals and 180 mm later) at GPR maintains BG at concentrations that should minimize biochemical abnormalities and optimize clinical outcome in patients with GSD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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