| Abstrakt: |
A dietary supplement of linoleic acid (LA) as soy phosphatidylcholine (PC) or as triglyceride on polymorpho- nuclear leukocyte (PMNL) functions, arachidonate (AA) con- centrations, AA release, and leukotriene B4 (LTB4) generation was studied in normal adults. Study 1 : Eight subjects were fed PC (27 g) or placebo for 3 d in a blinded crossover experiment with PMNL assays at baseline and 4, 7, and 14 d. Study 2: Subjects were fed equal quantities of LA as PC (18 g, n = 8), safflower (SF, n = 4), or soybean oil (SY, n = 4) with PMNL assays at baseline and 48 h. Study I : PC increased PMNL phagocytosis and killing of Candida albicans twofold (P < 0.001) and PMNL phospholipid AA content threefold (P < 0.001); AA release after Candida albicans stimulation increased 5.3-fold, correlating with PMNL killing (r = 0.932) and phagocytosis (r = 0.872). Study 2: PC, but not SF or SY, produced changes similar to those of study 1 . With PMNL exposure to calcium ionophore A23 1 87 or N-formyl-methionyl-leucyl-phenylanine, PC increased LTB4 generation. Phospholipid LA, in contrast to triglyceride LA, enhanced PMNL phospholipid AA, phagocytosis, and killing. [ABSTRACT FROM AUTHOR] |
